![]() ![]() At enrolment into the study cohort 66% were on antidiabetic treatment, among the patients included in this current study 71% started within one year prior to study start or after. We conducted this prevalence study using cross-sectional baseline data from DD2, a nationwide cohort study of newly diagnosed Type 2 DM patients enrolled from the practices of general practitioners (GPs) and hospital specialist outpatient clinics in Denmark since November 2010. As CRP is higher in females than males, we also wished to examine whether factors associated with elevated CRP in Type 2 DM differed between genders. We thus aimed to examine the prevalence of and modifiable factors associated with elevated CRP among newly diagnosed Type 2 DM patients included in the nationwide Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort study. Lower CRP levels have been reported among individuals with regular alcohol consumption and those under statin treatment. In cross-sectional studies of the general population, elevated levels of CRP are often found in older people, in those with high Body Mass Index, and in less physically active people. Information regarding elevated CRP levels and associated factors at the time of Type 2 DM diagnosis in a population-based setting is limited. Thus, for prevention purposes, early detection of elevated CRP levels and identification of modifiable factors associated with this condition are important. In patients with Type 2 diabetes mellitus (DM), the level of systemic inflammation, measured by C-reactive protein (CRP), may be a predictor of cardiovascular disease (CVD) and worse prognosis. Important modifiable risk factors for elevated CRP may vary by gender, and include low physical activity for men and central obesity and absence of statin use for women. ConclusionsĪmong newly diagnosed Type 2 DM patients, 40% had elevated CRP levels. The linear regression analysis conveyed an association between high CRP and increased fasting blood glucose. Sensitivity analyses showed consistent results with the full analysis. For both genders, elevated CRP was 1.4-fold increased in those with weight gain >30 kg since age 20 years. For men, CRP was primarily elevated among patients with no regular physical activity (aRR 1.5 (95% CI 1.1-1.9)), previous cardiovascular disease (aRR1.5 (95% CI 1.2-1.9) and other comorbidity. Among women, a lower risk of elevated CRP was observed in patients receiving statins (adjusted RR (aRR) 0.7 (95% confidence interval (CI) 0.6-0.9)), whereas a higher risk was seen in patients with central obesity (aRR 2.3 (95% CI 1.0-5.3)). More women (46%) than men (34%) had elevated CRP. In total, 405 out of the 1,037 Type 2 DM patients (40%) had elevated CRP levels (>3.0 mg/L). The median CRP value was 2.1 mg/L (interquartile range, 1.0 – 4.8 mg/L). We used linear regression to examine the association of CRP with other biomarkers. ![]() We assessed the prevalence of elevated CRP and calculated relative risks (RR) examining the association of CRP with lifestyle and clinical factors by Poisson regression, stratified by gender. MethodsĬRP was measured in 1,037 patients (57% male) with newly diagnosed Type 2 DM included in the prospective nationwide Danish Centre for Strategic Research in Type 2 Diabetes (DD2) project. We aimed to examine the prevalence of and modifiable factors associated with elevated C-reactive Protein (CRP), a marker of inflammation, in men and women with newly diagnosed Type 2 Diabetes mellitus (DM) in a population-based setting. ![]()
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